Grant Challen
Grant Challen
Washington University School of Medicine
Verified email at - Homepage
Cited by
Cited by
Dnmt3a is essential for hematopoietic stem cell differentiation
GA Challen, D Sun, M Jeong, M Luo, J Jelinek, JS Berg, C Bock, ...
Nature genetics 44 (1), 23-31, 2012
A side order of stem cells: the SP phenotype
GA Challen, MH Little
Stem cells 24 (1), 3-12, 2006
Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-β1
GA Challen, NC Boles, SM Chambers, MA Goodell
Cell stem cell 6 (3), 265-278, 2010
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
AL Young, GA Challen, BM Birmann, TE Druley
Nature communications 7 (1), 12484, 2016
Mouse hematopoietic stem cell identification and analysis
GA Challen, N Boles, KYK Lin, MA Goodell
Cytometry Part A: The Journal of the International Society for Advancement …, 2009
Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells
GA Challen, D Sun, A Mayle, M Jeong, M Luo, B Rodriguez, C Mallaney, ...
Cell stem cell 15 (3), 350-364, 2014
Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation
JI McDonald, H Celik, LE Rois, G Fishberger, T Fowler, R Rees, A Kramer, ...
Biology open 5 (6), 866-874, 2016
Large conserved domains of low DNA methylation maintained by Dnmt3a
M Jeong, D Sun, M Luo, Y Huang, GA Challen, B Rodriguez, X Zhang, ...
Nature genetics 46 (1), 17-23, 2014
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
A Mayle, L Yang, B Rodriguez, T Zhou, E Chang, CV Curry, GA Challen, ...
Blood, The Journal of the American Society of Hematology 125 (4), 629-638, 2015
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling
D Hormaechea-Agulla, KA Matatall, DT Le, B Kain, X Long, P Kus, ...
Cell stem cell 28 (8), 1428-1442. e6, 2021
Loss of Dnmt3a immortalizes hematopoietic stem cells in vivo
M Jeong, HJ Park, H Celik, EL Ostrander, JM Reyes, A Guzman, ...
Cell reports 23 (1), 1-10, 2018
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
MA Meyer, JM Baer, BL Knolhoff, TM Nywening, RZ Panni, X Su, ...
Nature communications 9 (1), 1250, 2018
Kidney side population reveals multilineage potential and renal functional capacity but also cellular heterogeneity
GA Challen, I Bertoncello, JA Deane, SD Ricardo, MH Little
Journal of the American Society of Nephrology 17 (7), 1896-1912, 2006
DNMT3A loss drives enhancer hypomethylation in FLT3-ITD-associated leukemias
L Yang, B Rodriguez, A Mayle, HJ Park, X Lin, M Luo, M Jeong, CV Curry, ...
Cancer cell 29 (6), 922-934, 2016
Identifying the molecular phenotype of renal progenitor cells
GA Challen, G Martinez, MJ Davis, DF Taylor, M Crowe, RD Teasdale, ...
Journal of the American Society of Nephrology 15 (9), 2344-2357, 2004
Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells
KA Matatall, CC Shen, GA Challen, KY King
Stem Cells 32 (11), 3023-3030, 2014
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells
GA Challen, MA Goodell
Experimental hematology 38 (5), 403-416, 2010
Clonal hematopoiesis: mechanisms driving dominance of stem cell clones
GA Challen, MA Goodell
Blood, The Journal of the American Society of Hematology 136 (14), 1590-1598, 2020
Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients
CRC Zhang, D Nix, M Gregory, MA Ciorba, EL Ostrander, RD Newberry, ...
Experimental hematology 80, 36-41. e3, 2019
Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation
H Celik, C Mallaney, A Kothari, EL Ostrander, E Eultgen, A Martens, ...
Blood, The Journal of the American Society of Hematology 125 (4), 619-628, 2015
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