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Samuel Lai
Samuel Lai
Verified email at unc.edu
Title
Cited by
Cited by
Year
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
SK Lai, YY Wang, J Hanes
Advanced drug delivery reviews 61 (2), 158-171, 2009
20082009
Micro-and macrorheology of mucus
SK Lai, YY Wang, D Wirtz, J Hanes
Advanced drug delivery reviews 61 (2), 86-100, 2009
13032009
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
SK Lai, DE O'Hanlon, S Harrold, ST Man, YY Wang, R Cone, J Hanes
Proceedings of the National Academy of Sciences 104 (5), 1482-1487, 2007
12322007
Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that “slip” through the human mucus barrier
YY Wang, SK Lai, JS Suk, A Pace, R Cone, J Hanes
Angewandte Chemie International Edition 47 (50), 9726-9729, 2008
6882008
Anti‐PEG immunity: emergence, characteristics, and unaddressed questions
Q Yang, SK Lai
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 7 (5 …, 2015
6262015
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier
BC Tang, M Dawson, SK Lai, YY Wang, JS Suk, M Yang, P Zeitlin, ...
Proceedings of the National Academy of Sciences 106 (46), 19268-19273, 2009
5292009
Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses
SK Lai, YY Wang, K Hida, R Cone, J Hanes
Proceedings of the National Academy of Sciences 107 (2), 598-603, 2010
4362010
The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles
JS Suk, SK Lai, YY Wang, LM Ensign, PL Zeitlin, MP Boyle, J Hanes
Biomaterials 30 (13), 2591-2597, 2009
3692009
PEGylation for enhancing nanoparticle diffusion in mucus
JT Huckaby, SK Lai
Advanced drug delivery reviews 124, 125-139, 2018
3622018
Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus
SK Lai, K Hida, S Shukair, YY Wang, A Figueiredo, R Cone, TJ Hope, ...
Journal of virology 83 (21), 11196-11200, 2009
3462009
Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway
SK Lai, K Hida, ST Man, C Chen, C Machamer, TA Schroer, J Hanes
Biomaterials 28 (18), 2876-2884, 2007
3282007
Analysis of pre-existing IgG and IgM antibodies against polyethylene glycol (PEG) in the general population
Q Yang, TM Jacobs, JD McCallen, DT Moore, JT Huckaby, JN Edelstein, ...
Analytical chemistry 88 (23), 11804-11812, 2016
3102016
Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation
Q Yang, SW Jones, CL Parker, WC Zamboni, JE Bear, SK Lai
Molecular pharmaceutics 11 (4), 1250-1258, 2014
3052014
Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus
M Yang, SK Lai, YY Wang, W Zhong, C Happe, M Zhang, J Fu, J Hanes
Angewandte Chemie 123 (11), 2645-2648, 2011
2852011
Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier
JS Suk, AJ Kim, K Trehan, CS Schneider, L Cebotaru, OM Woodward, ...
Journal of Controlled Release 178, 8-17, 2014
2082014
Convolutional neural networks automate detection for tracking of submicron-scale particles in 2D and 3D
JM Newby, AM Schaefer, PT Lee, MG Forest, SK Lai
Proceedings of the National Academy of Sciences 115 (36), 9026-9031, 2018
2062018
Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine
JS Suk, SK Lai, NJ Boylan, MR Dawson, MP Boyle, J Hanes
Nanomedicine 6 (2), 365-375, 2011
1912011
The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors
L Miao, JM Newby, CM Lin, L Zhang, F Xu, WY Kim, MG Forest, SK Lai, ...
ACS nano 10 (10), 9243-9258, 2016
1862016
Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles
JS Suk, J Suh, K Choy, SK Lai, J Fu, J Hanes
Biomaterials 27 (29), 5143-5150, 2006
1862006
Enhanced trapping of HIV-1 by human cervicovaginal mucus is associated with Lactobacillus crispatus-dominant microbiota
KL Nunn, YY Wang, D Harit, MS Humphrys, B Ma, R Cone, J Ravel, ...
MBio 6 (5), 10.1128/mbio. 01084-15, 2015
1852015
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