Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues SK Lai, YY Wang, J Hanes Advanced drug delivery reviews 61 (2), 158-171, 2009 | 2008 | 2009 |
Micro-and macrorheology of mucus SK Lai, YY Wang, D Wirtz, J Hanes Advanced drug delivery reviews 61 (2), 86-100, 2009 | 1303 | 2009 |
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus SK Lai, DE O'Hanlon, S Harrold, ST Man, YY Wang, R Cone, J Hanes Proceedings of the National Academy of Sciences 104 (5), 1482-1487, 2007 | 1232 | 2007 |
Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that “slip” through the human mucus barrier YY Wang, SK Lai, JS Suk, A Pace, R Cone, J Hanes Angewandte Chemie International Edition 47 (50), 9726-9729, 2008 | 688 | 2008 |
Anti‐PEG immunity: emergence, characteristics, and unaddressed questions Q Yang, SK Lai Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 7 (5 …, 2015 | 626 | 2015 |
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier BC Tang, M Dawson, SK Lai, YY Wang, JS Suk, M Yang, P Zeitlin, ... Proceedings of the National Academy of Sciences 106 (46), 19268-19273, 2009 | 529 | 2009 |
Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses SK Lai, YY Wang, K Hida, R Cone, J Hanes Proceedings of the National Academy of Sciences 107 (2), 598-603, 2010 | 436 | 2010 |
The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles JS Suk, SK Lai, YY Wang, LM Ensign, PL Zeitlin, MP Boyle, J Hanes Biomaterials 30 (13), 2591-2597, 2009 | 369 | 2009 |
PEGylation for enhancing nanoparticle diffusion in mucus JT Huckaby, SK Lai Advanced drug delivery reviews 124, 125-139, 2018 | 362 | 2018 |
Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus SK Lai, K Hida, S Shukair, YY Wang, A Figueiredo, R Cone, TJ Hope, ... Journal of virology 83 (21), 11196-11200, 2009 | 346 | 2009 |
Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway SK Lai, K Hida, ST Man, C Chen, C Machamer, TA Schroer, J Hanes Biomaterials 28 (18), 2876-2884, 2007 | 328 | 2007 |
Analysis of pre-existing IgG and IgM antibodies against polyethylene glycol (PEG) in the general population Q Yang, TM Jacobs, JD McCallen, DT Moore, JT Huckaby, JN Edelstein, ... Analytical chemistry 88 (23), 11804-11812, 2016 | 310 | 2016 |
Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation Q Yang, SW Jones, CL Parker, WC Zamboni, JE Bear, SK Lai Molecular pharmaceutics 11 (4), 1250-1258, 2014 | 305 | 2014 |
Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus M Yang, SK Lai, YY Wang, W Zhong, C Happe, M Zhang, J Fu, J Hanes Angewandte Chemie 123 (11), 2645-2648, 2011 | 285 | 2011 |
Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier JS Suk, AJ Kim, K Trehan, CS Schneider, L Cebotaru, OM Woodward, ... Journal of Controlled Release 178, 8-17, 2014 | 208 | 2014 |
Convolutional neural networks automate detection for tracking of submicron-scale particles in 2D and 3D JM Newby, AM Schaefer, PT Lee, MG Forest, SK Lai Proceedings of the National Academy of Sciences 115 (36), 9026-9031, 2018 | 206 | 2018 |
Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine JS Suk, SK Lai, NJ Boylan, MR Dawson, MP Boyle, J Hanes Nanomedicine 6 (2), 365-375, 2011 | 191 | 2011 |
The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors L Miao, JM Newby, CM Lin, L Zhang, F Xu, WY Kim, MG Forest, SK Lai, ... ACS nano 10 (10), 9243-9258, 2016 | 186 | 2016 |
Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles JS Suk, J Suh, K Choy, SK Lai, J Fu, J Hanes Biomaterials 27 (29), 5143-5150, 2006 | 186 | 2006 |
Enhanced trapping of HIV-1 by human cervicovaginal mucus is associated with Lactobacillus crispatus-dominant microbiota KL Nunn, YY Wang, D Harit, MS Humphrys, B Ma, R Cone, J Ravel, ... MBio 6 (5), 10.1128/mbio. 01084-15, 2015 | 185 | 2015 |