Jakob von Moltke
Jakob von Moltke
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Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit
J Von Moltke, M Ji, HE Liang, RM Locksley
Nature 529 (7585), 221-225, 2016
Type 2 innate lymphoid cells control eosinophil homeostasis
JC Nussbaum, SJ Van Dyken, J von Moltke, LE Cheng, A Mohapatra, ...
Nature 502 (7470), 245, 2013
Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
P Broz, J von Moltke, JW Jones, RE Vance, DM Monack
Cell host & microbe 8 (6), 471-483, 2010
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic …
JD Sauer, K Sotelo-Troha, J Von Moltke, KM Monroe, CS Rae, ...
Infection and immunity 79 (2), 688-694, 2011
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
KL Lightfield, J Persson, SW Brubaker, CE Witte, J Von Moltke, ...
Nature immunology 9 (10), 1171-1178, 2008
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo
J von Moltke, NJ Trinidad, M Moayeri, AF Kintzer, SB Wang, ...
Nature 490 (7418), 107-111, 2012
Recognition of bacteria by inflammasomes
J von Moltke, JS Ayres, EM Kofoed, J Chavarría-Smith, RE Vance
Annual review of immunology 31, 73-106, 2013
Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit
MS Nadjsombati, JW McGinty, MR Lyons-Cohen, JB Jaffe, L DiPeso, ...
Immunity 49 (1), 33-41. e7, 2018
NAIP-NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of caspase-1 and-8
I Rauch, KA Deets, DX Ji, J von Moltke, JL Tenthorey, AY Lee, NH Philip, ...
Immunity 46 (4), 649-659, 2017
A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling
C Schneider, CE O’Leary, J von Moltke, HE Liang, QY Ang, PJ Turnbaugh, ...
Cell 174 (2), 271-284. e14, 2018
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development
CN Miller, I Proekt, J von Moltke, KL Wells, AR Rajpurkar, H Wang, ...
Nature 559 (7715), 627-631, 2018
Differential activation of the transcription factor IRF1 underlies the distinct immune responses elicited by type I and type III interferons
A Forero, S Ozarkar, H Li, CH Lee, EA Hemann, MS Nadjsombati, ...
Immunity 51 (3), 451-464. e6, 2019
Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency
CM Quinzii, LC López, J Von-Moltke, A Naini, S Krishna, M Schuelke, ...
The FASEB journal: official publication of the Federation of American …, 2008
Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s
J von Moltke, CE O’Leary, NA Barrett, Y Kanaoka, KF Austen, ...
Journal of Experimental Medicine 214 (1), 27-37, 2017
Tuft-cell-derived leukotrienes drive rapid anti-helminth immunity in the small intestine but are dispensable for anti-protist immunity
JW McGinty, HA Ting, TE Billipp, MS Nadjsombati, DM Khan, NA Barrett, ...
Immunity 52 (3), 528-541. e7, 2020
The cysteinyl leukotriene 3 receptor regulates expansion of IL-25–producing airway brush cells leading to type 2 inflammation
LG Bankova, DF Dwyer, E Yoshimoto, S Ualiyeva, JW McGinty, H Raff, ...
Science immunology 3 (28), eaat9453, 2018
The immune function of tuft cells at gut mucosal surfaces and beyond
HA Ting, J von Moltke
The Journal of Immunology 202 (5), 1321-1329, 2019
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation
PB Singh, HH Pua, HC Happ, C Schneider, J von Moltke, RM Locksley, ...
Journal of Experimental Medicine 214 (12), 3627-3643, 2017
Interpreting heterogeneity in intestinal tuft cell structure and function
A Banerjee, ET McKinley, J von Moltke, RJ Coffey, KS Lau
The Journal of clinical investigation 128 (5), 1711-1719, 2018
ILC-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis
J von Moltke, RM Locksley
Current opinion in immunology 31, 58-65, 2014
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