John P. Overington
John P. Overington
CTO, Exscientia
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How many drug targets are there?
JP Overington, B Al-Lazikani, AL Hopkins
Nature Reviews Drug Discovery 5 (12), 993-996, 2006
ChEMBL: a large-scale bioactivity database for drug discovery
A Gaulton, LJ Bellis, AP Bento, J Chambers, M Davies, A Hersey, Y Light, ...
Nucleic Acids Research 40, D1100-1107, 2012
The ChEMBL database in 2017
A Gaulton, A Hersey, M Nowotka, AP Bento, J Chambers, D Mendez, ...
Nucleic acids research 45 (D1), D945-D954, 2017
A comprehensive map of molecular drug targets
R Santos, O Ursu, A Gaulton, AP Bento, RS Donadi, CG Bologa, ...
Nature reviews Drug discovery 16 (1), 19-34, 2017
The ChEMBL bioactivity database: an update
AP Bento, A Gaulton, A Hersey, LJ Bellis, J Chambers, M Davies, ...
Nucleic acids research 42 (D1), D1083-D1090, 2014
An atlas of genetic influences on human blood metabolites
SY Shin, EB Fauman, AK Petersen, J Krumsiek, R Santos, J Huang, ...
Nature Genetics 46, 543-540, 2014
The genome of the blood fluke Schistosoma mansoni
M Berriman, BJ Haas, PT LoVerde, RA Wilson, GP Dillon, GC Cerqueira, ...
Nature 460 (7253), 352-358, 2009
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
A community effort to assess and improve drug sensitivity prediction algorithms.
WK Costello JC, Heiser LM, Georgii E, Gönen M, Menden MP, Wang NJ, Bansal M ...
Nat Biotechnol. 32 (6), 2014
HOMSTRAD: a database of protein structure alignments for homologous families
K Mizuguchi, CM Deane, TL Blundell, JP Overington
Protein Science 7 (11), 2469-2471, 1998
X-ray analysis of HIV-1 proteinase at 2.7A resolution confirms structural homology among retroviral enzymes
R Lapatto, T Blundell, A Hemmings, J Overington, A Wilderspin, S Wood, ...
Nature 342 (6247), 299-302, 1989
Can we rationally design promiscuous drugs?
AL Hopkins, JS Mason, JP Overington
Current Opinion In Structural Biology 16 (1), 127-136, 2006
ChEMBL web services: streamlining access to drug discovery data and utilities
M Davies, M Nowotka, G Papadatos, N Dedman, A Gaulton, F Atkinson, ...
Nucleic acids research 43 (W1), W612-W620, 2015
Probing the links between in vitro potency, ADMET and physicochemical parameters
MP Gleeson, A Hersey, D Montanari, J Overington
Nature reviews Drug discovery 10 (3), 197-208, 2011
The druggable genome and support for target identification and validation in drug development
C Finan, A Gaulton, FA Kruger, RT Lumbers, T Shah, J Engmann, ...
Science translational medicine 9 (383), eaag1166, 2017
JOY: protein sequence-structure representation and analysis.
K Mizuguchi, CM Deane, TL Blundell, MS Johnson, JP Overington
Bioinformatics 14 (7), 617-623, 1998
A Structural Basis for Sequence Comparisons: An Evaluation of Scoring Methodologies
MS Johnson, JP Overington
Journal of Molecular Biology 233 (4), 716-738, 1993
Environment‐specific amino acid substitution tables: Tertiary templates and prediction of protein folds
J Overington, D Donnelly, MS Johnson, A Šali, TL Blundell
Protein Science 1 (2), 216-226, 1992
Derivation of rules for comparative protein modeling from a database of protein structure alignments
A Šali, JP Overington
Protein Science 3 (9), 1582-1596, 1994
Unexplored therapeutic opportunities in the human genome
TI Oprea, CG Bologa, S Brunak, A Campbell, GN Gan, A Gaulton, ...
Nature reviews Drug discovery 17 (5), 317-332, 2018
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