Something from “nothing”− eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects E Silva, N Rajapakse, A Kortenkamp Environmental science & technology 36 (8), 1751-1756, 2002 | 1075 | 2002 |
Combining xenoestrogens at levels below individual no-observed-effect concentrations dramatically enhances steroid hormone action. N Rajapakse, E Silva, A Kortenkamp Environmental health perspectives 110 (9), 917-921, 2002 | 575 | 2002 |
Deviation from additivity with estrogenic mixtures containing 4-nonylphenol and 4-tert-octylphenol detected in the E-SCREEN assay N Rajapakse, E Silva, M Scholze, A Kortenkamp Environmental science & technology 38 (23), 6343-6352, 2004 | 132 | 2004 |
Cross-talk between non-genomic and genomic signalling pathways—distinct effect profiles of environmental estrogens E Silva, A Kabil, A Kortenkamp Toxicology and applied pharmacology 245 (2), 160-170, 2010 | 101 | 2010 |
Lack of activity of cadmium in in vitro estrogenicity assays E Silva, MJ Lopez-Espinosa, JM Molina-Molina, M Fernández, N Olea, ... Toxicology and applied pharmacology 216 (1), 20-28, 2006 | 83 | 2006 |
Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer G Corda, G Sala, R Lattanzio, M Iezzi, M Sallese, G Fragassi, ... The Journal of pathology 241 (3), 350-361, 2017 | 80 | 2017 |
Combination effects of amphetamines under hyperthermia‐the role played by oxidative stress DD Da Silva, E Silva, H Carmo Journal of Applied Toxicology 34 (6), 637-650, 2014 | 77 | 2014 |
Disruption of 3D MCF-12A Breast Cell Cultures by Estrogens – An In Vitro Model for ER-Mediated Changes Indicative of Hormonal Carcinogenesis S Marchese, E Silva Public Library of Science 7 (10), e45767, 2012 | 68 | 2012 |
An insight into the hepatocellular death induced by amphetamines, individually and in combination: the involvement of necrosis and apoptosis D Dias da Silva, H Carmo, A Lynch, E Silva Archives of toxicology 87, 2165-2185, 2013 | 67 | 2013 |
Extending the applicability of the dose addition model to the assessment of chemical mixtures of partial agonists by using a novel toxic unit extrapolation method M Scholze, E Silva, A Kortenkamp PloS one 9 (2), e88808, 2014 | 59 | 2014 |
Combined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal symptoms C Gérard, M Mestdagt, E Tskitishvili, L Communal, A Gompel, E Silva, ... Oncotarget 6 (19), 17621, 2015 | 56 | 2015 |
Joint effects of heterogeneous estrogenic chemicals in the e-screen—exploring the applicability of concentration addition E Silva, N Rajapakse, M Scholze, T Backhaus, S Ermler, A Kortenkamp Toxicological Sciences 122 (2), 383-394, 2011 | 49 | 2011 |
Activity of xenoestrogens at nanomolar concentrations in the E-Screen assay E Silva, M Scholze, A Kortenkamp Environmental health perspectives 115 (Suppl 1), 91-97, 2007 | 49 | 2007 |
Estrogens and genomic instability in human breast cancer cells—involvement of Src/Raf/Erk signaling in micronucleus formation by estrogenic chemicals A Kabil, E Silva, A Kortenkamp Carcinogenesis 29 (10), 1862-1868, 2008 | 48 | 2008 |
A review of biomaterials and scaffold fabrication for organ-on-a-chip (OOAC) systems LA Osório, E Silva, RE Mackay Bioengineering 8 (8), 113, 2021 | 43 | 2021 |
Assessment of the total effective xenoestrogen burden in extracts of human placentas MJ Lopez-Espinosa, E Silva, A Granada, JM Molina-Molina, ... Biomarkers 14 (5), 271-277, 2009 | 39 | 2009 |
The risky cocktail: what combination effects can we expect between ecstasy and other amphetamines? D Dias da Silva, H Carmo, E Silva Archives of toxicology 87, 111-122, 2013 | 29 | 2013 |
Safety of herbal medicinal products: Echinacea and selected alkylamides do not induce CYP3A4 mRNA expression M Modarai, E Silva, A Suter, M Heinrich, A Kortenkamp Evidence-Based Complementary and Alternative Medicine 2011, 2011 | 29 | 2011 |
Mixtures of 3,4‐methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when … DD da Silva, E Silva, F Carvalho, H Carmo Journal of Applied Toxicology 34 (6), 618-627, 2014 | 28 | 2014 |
Cytotoxic effects of amphetamine mixtures in primary hepatocytes are severely aggravated under hyperthermic conditions DD da Silva, E Silva, H Carmo Toxicology in Vitro 27 (6), 1670-1678, 2013 | 26 | 2013 |