Philip J. Kranzusch, Ph.D.
Philip J. Kranzusch, Ph.D.
Professor, Harvard Medical School, Dana-Farber Cancer Institute
Verified email at - Homepage
Cited by
Cited by
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
JE Carette, M Raaben, AC Wong, AS Herbert, G Obernosterer, ...
Nature 477 (7364), 340-343, 2011
Origin of the human malaria parasite Plasmodium falciparum in gorillas
W Liu, Y Li, GH Learn, RS Rudicell, JD Robertson, BF Keele, ...
Nature 467 (7314), 420-425, 2010
Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity
JK Nuņez, PJ Kranzusch, J Noeske, AV Wright, CW Davies, JA Doudna
Nature structural & molecular biology 21 (6), 528-534, 2014
eIF3 targets cell-proliferation messenger RNAs for translational activation or repression
ASY Lee, PJ Kranzusch, JHD Cate
Nature 522 (7554), 111-114, 2015
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity
PJ Kranzusch, ASY Lee, JM Berger, JA Doudna
Cell reports 3 (5), 1362-1368, 2013
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
ASY Lee, PJ Kranzusch, JA Doudna, JHD Cate
Nature 536 (7614), 96-99, 2016
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals
AT Whiteley, JB Eaglesham, CC de Oliveira Mann, BR Morehouse, ...
Nature 567 (7747), 194-199, 2019
A broad-spectrum inhibitor of CRISPR-Cas9
LB Harrington, KW Doxzen, E Ma, JJ Liu, GJ Knott, A Edraki, B Garcia, ...
Cell 170 (6), 1224-1233. e15, 2017
Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance
W Zhou, AT Whiteley, CC de Oliveira Mann, BR Morehouse, RP Nowak, ...
Cell 174 (2), 300-311. e11, 2018
African origin of the malaria parasite Plasmodium vivax
W Liu, Y Li, KS Shaw, GH Learn, LJ Plenderleith, JA Malenke, ...
Nature communications 5 (1), 3346, 2014
Ancient origin of cGAS-STING reveals mechanism of universal 2′, 3′ cGAMP signaling
PJ Kranzusch, SC Wilson, ASY Lee, JM Berger, JA Doudna, RE Vance
Molecular cell 59 (6), 891-903, 2015
STING cyclic dinucleotide sensing originated in bacteria
BR Morehouse, AA Govande, A Millman, AFA Keszei, B Lowey, G Ofir, ...
Nature 586 (7829), 429-433, 2020
Foreign DNA capture during CRISPR–Cas adaptive immunity
JK Nuņez, LB Harrington, PJ Kranzusch, AN Engelman, JA Doudna
Nature 527 (7579), 535-538, 2015
Phosphoinositide interactions position cGAS at the plasma membrane to ensure efficient distinction between self-and viral DNA
KC Barnett, JM Coronas-Serna, W Zhou, MJ Ernandes, A Cao, ...
Cell 176 (6), 1432-1446. e11, 2019
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
JB Eaglesham, Y Pan, TS Kupper, PJ Kranzusch
Nature 566 (7743), 259-263, 2019
Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin
SR Radoshitzky, L Dong, X Chi, JC Clester, C Retterer, K Spurgers, ...
Journal of virology 84 (20), 10569-10580, 2010
Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity
RK Lau, Q Ye, EA Birkholz, KR Berg, L Patel, IT Mathews, JD Watrous, ...
Molecular cell 77 (4), 723-733. e6, 2020
Modular architecture of the STING C-terminal tail allows interferon and NF-κB signaling adaptation
CC de Oliveira Mann, MH Orzalli, DS King, JC Kagan, ASY Lee, ...
Cell reports 27 (4), 1165-1175. e5, 2019
CBASS immunity uses CARF-related effectors to sense 3′–5′-and 2′–5′-linked cyclic oligonucleotide signals and protect bacteria from phage infection
B Lowey, AT Whiteley, AFA Keszei, BR Morehouse, IT Mathews, ...
Cell 182 (1), 38-49. e17, 2020
A bacterial Argonaute with noncanonical guide RNA specificity
E Kaya, KW Doxzen, KR Knoll, RC Wilson, SC Strutt, PJ Kranzusch, ...
Proceedings of the National Academy of Sciences 113 (15), 4057-4062, 2016
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