Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation A Talavera, R Friemann, S Gómez-Puerta, C Martinez-Fleites, G Garrido, ... Cancer research 69 (14), 5851-5859, 2009 | 255 | 2009 |
Direct activation of a bacterial innate immune system by a viral capsid protein T Zhang, H Tamman, K Coppieters’t Wallant, T Kurata, M LeRoux, ... Nature 612 (7938), 132-140, 2022 | 94 | 2022 |
Light-chain shuffling results in successful phage display selection of functional prokaryotic-expressed antibody fragments to N-glycolyl GM3 ganglioside G Rojas, A Talavera, Y Munoz, E Rengifo, U Krengel, J Ĺngström, ... Journal of immunological methods 293 (1-2), 71-83, 2004 | 68 | 2004 |
Structure and molecular interactions of a unique antitumor antibody specific for N-glycolyl GM3 U Krengel, LL Olsson, C Martínez, A Talavera, G Rojas, E Mier, ... Journal of Biological Chemistry 279 (7), 5597-5603, 2004 | 62 | 2004 |
Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol JB Startek, B Boonen, A Lopez-Requena, A Talavera, YA Alpizar, ... Elife 8, e46084, 2019 | 52 | 2019 |
Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics V Zorzini, L Buts, M Sleutel, A Garcia-Pino, A Talavera, S Haesaerts, ... Nucleic Acids Research 42 (10), 6709-6725, 2014 | 48 | 2014 |
A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes H Tamman, K Van Nerom, H Takada, N Vandenberk, D Scholl, ... Nature Chemical Biology 16 (8), 834-840, 2020 | 47 | 2020 |
Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors A Talavera, J Hendrix, W Versées, D Jurėnas, K Van Nerom, ... Science advances 4 (3), eaap9714, 2018 | 41 | 2018 |
An intrinsically disordered entropic switch determines allostery in Phd–Doc regulation A Garcia-Pino, S De Gieter, A Talavera, H De Greve, RG Efremov, R Loris Nature chemical biology 12 (7), 490-496, 2016 | 40 | 2016 |
A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT A Talavera, H Tamman, A Ainelo, A Konijnenberg, S Hadži, F Sobott, ... Nature communications 10 (1), 972, 2019 | 35 | 2019 |
Crystal structure of an anti-ganglioside antibody, and modelling of the functional mimicry of its NeuGc-GM3 antigen by an anti-idiotypic antibody A Talavera, A Eriksson, M Ökvist, A López-Requena, ... Molecular Immunology 46 (16), 3466-3475, 2009 | 35 | 2009 |
Gangliosides, Ab1 and Ab2 antibodies: I. Towards a molecular dissection of an idiotype–anti-idiotype system A López-Requena, CM De Acosta, E Moreno, M González, Y Puchades, ... Molecular Immunology 44 (4), 423-433, 2007 | 31 | 2007 |
Structural insights into serine protease inhibition by a marine invertebrate BPTI Kunitz-type inhibitor R García-Fernández, T Pons, M Perbandt, PA Valiente, A Talavera, ... Journal of structural biology 180 (2), 271-279, 2012 | 29 | 2012 |
(p) ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains M Roghanian, K Van Nerom, H Takada, J Caballero-Montes, H Tamman, ... Molecular cell 81 (16), 3310-3322. e6, 2021 | 27 | 2021 |
TRPA1 gene variants hurting our feelings R Naert, A Talavera, JB Startek, K Talavera Pflügers Archiv-European Journal of Physiology 472, 953-960, 2020 | 20 | 2020 |
Gangliosides, Ab1 and Ab2 antibodies: II. Light versus heavy chain: An idiotype-anti-idiotype case study A López-Requena, M Rodríguez, CM de Acosta, E Moreno, Y Puchades, ... Molecular Immunology 44 (5), 1015-1028, 2007 | 20 | 2007 |
The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding S De Gieter, A Konijnenberg, A Talavera, A Butterer, S Haesaerts, ... Journal of Biological Chemistry 289 (49), 34013-34023, 2014 | 14 | 2014 |
The citrus flavanone hesperetin preferentially inhibits slow‐inactivating currents of a long QT syndrome type 3 syndrome Na+ channel mutation J Alvarez‐Collazo, A López‐Requena, L Galán, A Talavera, JL Alvarez, ... British Journal of Pharmacology 176 (8), 1090-1105, 2019 | 13 | 2019 |
Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint H Tamman, K Ernits, M Roghanian, A Ainelo, C Julius, A Perrier, ... Nature chemical biology 19 (3), 334-345, 2023 | 10 | 2023 |
Structure of the Fab fragment of the anti-murine EGFR antibody 7A7 and exploration of its receptor binding site A Talavera, J Mackenzie, G Garrido, R Friemann, A López-Requena, ... Molecular Immunology 48 (12-13), 1578-1585, 2011 | 10 | 2011 |