Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation AH de la Peņa, EA Goodall, SN Gates, GC Lander, A Martin Science 362 (6418), eaav0725, 2018 | 297 | 2018 |
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104 SN Gates, AL Yokom, JB Lin, ME Jackrel, AN Rizo, NM Kendsersky, ... Science 357 (6348), 273-279, 2017 | 268 | 2017 |
Polyphosphate: a conserved modifier of amyloidogenic processes CM Cremers, D Knoefler, S Gates, N Martin, JU Dahl, J Lempart, L Xie, ... Molecular cell 63 (5), 768-780, 2016 | 161 | 2016 |
Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation AL Yokom, SN Gates, ME Jackrel, KL Mack, M Su, J Shorter, ... Nature structural & molecular biology 23 (9), 830-837, 2016 | 118 | 2016 |
Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase AN Rizo, JB Lin, SN Gates, E Tse, SM Bart, LM Castellano, F DiMaio, ... Nature communications 10 (1), 2393, 2019 | 105 | 2019 |
Stairway to translocation: AAA+ motor structures reveal the mechanisms of ATP‐dependent substrate translocation SN Gates, A Martin Protein Science 29 (2), 407-419, 2020 | 102 | 2020 |
The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions W Voth, M Schick, S Gates, S Li, F Vilardi, I Gostimskaya, DR Southworth, ... Molecular Cell 56 (1), 116-127, 2014 | 78 | 2014 |
Multisystem proteinopathy mutations in VCP/p97 increase NPLOC4· UFD1L binding and substrate processing EE Blythe, SN Gates, RJ Deshaies, A Martin Structure 27 (12), 1820-1829. e4, 2019 | 65 | 2019 |
The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state K Lee, AC Thwin, CM Nadel, E Tse, SN Gates, JE Gestwicki, ... Molecular cell 81 (17), 3496-3508. e5, 2021 | 64 | 2021 |
Mining disaggregase sequence space to safely counter TDP-43, FUS, and α-synuclein proteotoxicity A Tariq, JB Lin, ME Jackrel, CD Hesketh, PJ Carman, KL Mack, ... Cell reports 28 (8), 2080-2095. e6, 2019 | 47 | 2019 |
A pentameric protein ring with novel architecture is required for herpesviral packaging AL Didychuk, SN Gates, MR Gardner, LM Strong, A Martin, ... Elife 10, e62261, 2021 | 14 | 2021 |
Structures of the substrate-engaged 26S proteasome reveal the mechanisms for ATP hydrolysis-driven translocation AH de la Pena, EA Goodall, SN Gates, GC Lander, A Martin bioRxiv, 393223, 2018 | 3 | 2018 |
Design principles to tailor Hsp104 therapeutics JB Lin, PJ Carman, CW Gambogi, NM Kendsersky, E Chuang, SN Gates, ... bioRxiv, 2024 | | 2024 |
Understanding Protein Folding Mechanisms of Chaperone Proteins Using Cryo-EM S Gates | | 2017 |