| 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition S Banerjee, A Bartesaghi, A Merk, P Rao, SL Bulfer, Y Yan, N Green, ... Science 351 (6275), 871-875, 2016 | 371 | 2016 |
| Rigid nonlabile polyoxometalate cryptates [ZP5W30O110](15-n)-that exhibit unprecedented selectivity for certain lanthanide and other multivalent cations I Creaser, MC Heckel, RJ Neitz, MT Pope Inorganic Chemistry 32 (9), 1573-1578, 1993 | 225 | 1993 |
| Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl Sulfones BR Shenai, BJ Lee, A Alvarez-Hernandez, PY Chong, CD Emal, RJ Neitz, ... Antimicrobial agents and chemotherapy 47 (1), 154-160, 2003 | 202 | 2003 |
| Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease S Khare, SL Roach, SW Barnes, D Hoepfner, JR Walker, AK Chatterjee, ... PLoS Pathogens 11 (7), e1005058, 2015 | 67 | 2015 |
| Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni T Long, RJ Neitz, R Beasley, C Kalyanaraman, BM Suzuki, MP Jacobson, ... PLoS neglected tropical diseases 10 (1), e0004356, 2016 | 62 | 2016 |
| Studies on the synthesis of landomycin A. Synthesis of the originally assigned structure of the aglycone, landomycinone, and revision of structure WR Roush, RJ Neitz The Journal of Organic Chemistry 69 (15), 4906-4912, 2004 | 59 | 2004 |
| Structure–activity study of bioisosteric trifluoromethyl and pentafluorosulfanyl indole inhibitors of the AAA ATPase p97 C Alverez, MR Arkin, SL Bulfer, R Colombo, M Kovaliov, MG LaPorte, ... ACS medicinal chemistry letters 6 (12), 1225-1230, 2015 | 58 | 2015 |
| Selective and brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) inhibitors that reduce α‐synuclein phosphorylation in rat brain DL Aubele, RK Hom, M Adler, RA Galemmo Jr, S Bowers, AP Truong, ... ChemMedChem 8 (8), 1295-1313, 2013 | 53 | 2013 |
| Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2 S Gahbauer, GJ Correy, M Schuller, MP Ferla, YU Doruk, M Rachman, ... Proceedings of the National Academy of Sciences 120 (2), e2212931120, 2023 | 52 | 2023 |
| Lead identification to clinical candidate selection: drugs for Chagas disease RJ Neitz, S Chen, F Supek, V Yeh, D Kellar, J Gut, C Bryant, ... Journal of biomolecular screening 20 (1), 101-111, 2015 | 40 | 2015 |
| Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor S Bowers, AP Truong, RJ Neitz, M Neitzel, GD Probst, RK Hom, ... Bioorganic & medicinal chemistry letters 21 (6), 1838-1843, 2011 | 39 | 2011 |
| Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use … J Wu, JS Tung, ED Thorsett, MA Pleiss, JS Nissen, RJ Neitz, LH Latimer, ... US Patent 6,632,811, 2003 | 39 | 2003 |
| Novel cinnoline-based inhibitors of LRRK2 kinase activity AW Garofalo, M Adler, DL Aubele, S Bowers, M Franzini, E Goldbach, ... Bioorganic & medicinal chemistry letters 23 (1), 71-74, 2013 | 38 | 2013 |
| Allosteric indole amide inhibitors of p97: identification of a novel probe of the ubiquitin pathway C Alverez, SL Bulfer, R Chakrasali, MS Chimenti, RJ Deshaies, N Green, ... ACS medicinal chemistry letters 7 (2), 182-187, 2016 | 32 | 2016 |
| Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration S Bowers, AP Truong, RJ Neitz, RK Hom, JM Sealy, GD Probst, D Quincy, ... Bioorganic & medicinal chemistry letters 21 (18), 5521-5527, 2011 | 31 | 2011 |
| Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors S Bowers, AP Truong, M Ye, DL Aubele, JM Sealy, RJ Neitz, RK Hom, ... Bioorganic & medicinal chemistry letters 23 (9), 2743-2749, 2013 | 28 | 2013 |
| Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK RK Hom, S Bowers, JM Sealy, AP Truong, GD Probst, ML Neitzel, ... Bioorganic & medicinal chemistry letters 20 (24), 7303-7307, 2010 | 28 | 2010 |
| Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas’ disease RJ Neitz, C Bryant, S Chen, J Gut, EH Caselli, S Ponce, S Chowdhury, ... Bioorganic & medicinal chemistry letters 25 (21), 4834-4837, 2015 | 23 | 2015 |
| Optimization of phenyl indole inhibitors of the AAA+ ATPase p97 MG LaPorte, JC Burnett, R Colombo, SL Bulfer, C Alverez, TF Chou, ... ACS medicinal chemistry letters 9 (11), 1075-1081, 2018 | 20 | 2018 |
| A fragment-based ligand screen against part of a large protein machine: the ND1 domains of the AAA+ ATPase p97/VCP MS Chimenti, SL Bulfer, RJ Neitz, AR Renslo, MP Jacobson, TL James, ... Journal of Biomolecular Screening 20 (6), 788-800, 2015 | 19 | 2015 |
