Matilda S. Newton
Matilda S. Newton
Post Doctoral Fellow, University of Colorado
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Enzyme evolution: innovation is easy, optimization is complicated
MS Newton, VL Arcus, ML Gerth, WM Patrick
Current opinion in structural biology 48, 110-116, 2018
In Vitro Selection of Peptides and Proteins—Advantages of mRNA Display
MS Newton, Y Cabezas-Perusse, CL Tong, B Seelig
ACS Synthetic Biology 9 (2), 181-190, 2019
Rapid bursts and slow declines: on the possible evolutionary trajectories of enzymes
MS Newton, VL Arcus, WM Patrick
Journal of The Royal Society Interface 12 (107), 20150036, 2015
Structural and functional innovations in the real-time evolution of new (βα) 8 barrel enzymes
MS Newton, X Guo, A Söderholm, J Näsvall, P Lundström, DI Andersson, ...
Proceedings of the National Academy of Sciences 114 (18), 4727-4732, 2017
Two-step ligand binding in a (βα) 8 barrel enzyme-substrate-bound structures shed new light on the catalytic cycle of HisA
A Söderholm, X Guo, MS Newton, GB Evans, J Näsvall, WM Patrick, ...
Journal of Biological Chemistry, jbc. M115. 678086, 2015
Genetic Code Evolution Investigated through the Synthesis and Characterisation of Proteins from Reduced‐Alphabet Libraries
MS Newton, DJ Morrone, KH Lee, B Seelig
ChemBioChem 20 (6), 846-856, 2019
How to recruit a promiscuous enzyme to serve a new function
SD Copley, MS Newton, KA Widney
Biochemistry 62 (2), 300-308, 2022
A method for generating user-defined circular single-stranded DNA from plasmid DNA using Golden Gate intramolecular ligation
IK Strawn, PJ Steiner, MS Newton, ZT Baumer, TA Whitehead
Biotechnology and Bioengineering, 2023
On the Evolution of Catalysis: The changing kinetics of core metabolic enzymes
MS Newton
University of Otago, 2015
Cell survival enabled by leakage of a labile metabolic intermediate
E Medina-Carmona, LI Gutierrez-Rus, F Manssour-Triedo, MS Newton, ...
Molecular Biology and Evolution 40 (3), msad032, 2023
Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
A Söderholm, MS Newton, WM Patrick, M Selmer
Journal of Biological Chemistry 295 (47), 15948-15956, 2020
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