Wesley R Legant
Wesley R Legant
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Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution
BC Chen, WR Legant, K Wang, L Shao, DE Milkie, MW Davidson, ...
Science 346 (6208), 1257998, 2014
Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels
S Khetan, M Guvendiren, WR Legant, DM Cohen, CS Chen, JA Burdick
Nature materials 12 (5), 458-465, 2013
Applying systems-level spectral imaging and analysis to reveal the organelle interactome
AM Valm, S Cohen, WR Legant, J Melunis, U Hershberg, E Wait, ...
Nature 546 (7656), 162-167, 2017
Measurement of mechanical tractions exerted by cells in three-dimensional matrices
WR Legant, JS Miller, BL Blakely, DM Cohen, GM Genin, CS Chen
Nature methods 7 (12), 969-971, 2010
Single-molecule dynamics of enhanceosome assembly in embryonic stem cells
J Chen, Z Zhang, L Li, BC Chen, A Revyakin, B Hajj, W Legant, M Dahan, ...
Cell 156 (6), 1274-1285, 2014
Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues
WR Legant, A Pathak, MT Yang, VS Deshpande, RM McMeeking, ...
Proceedings of the National Academy of Sciences 106 (25), 10097-10102, 2009
A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues
T Boudou, WR Legant, A Mu, MA Borochin, N Thavandiran, M Radisic, ...
Tissue Engineering Part A 18 (9-10), 910-919, 2012
Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER
J Nixon-Abell, CJ Obara, AV Weigel, D Li, WR Legant, CS Xu, HA Pasolli, ...
Science 354 (6311), aaf3928, 2016
Actin depletion initiates events leading to granule secretion at the immunological synapse
AT Ritter, Y Asano, JC Stinchcombe, NMG Dieckmann, BC Chen, ...
Immunity 42 (5), 864-876, 2015
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
WR Legant, CK Choi, JS Miller, L Shao, L Gao, E Betzig, CS Chen
Proceedings of the National Academy of Sciences 110 (3), 881-886, 2013
High-density three-dimensional localization microscopy across large volumes
WR Legant, L Shao, JB Grimm, TA Brown, DE Milkie, BB Avants, LD Lavis, ...
Nature methods 13 (4), 359-365, 2016
Bioactive hydrogels made from step-growth derived PEG–peptide macromers
JS Miller, CJ Shen, WR Legant, JD Baranski, BL Blakely, CS Chen
Biomaterials 31 (13), 3736-3743, 2010
Phase separation drives aberrant chromatin looping and cancer development
JH Ahn, ES Davis, TA Daugird, S Zhao, IY Quiroga, H Uryu, J Li, AJ Storey, ...
Nature 595 (7868), 591-595, 2021
3D imaging of Sox2 enhancer clusters in embryonic stem cells
Z Liu, WR Legant, BC Chen, L Li, JB Grimm, LD Lavis, E Betzig, R Tjian
elife 3, e04236, 2014
Carbofluoresceins and carborhodamines as scaffolds for high-contrast fluorogenic probes
JB Grimm, AJ Sung, WR Legant, P Hulamm, SM Matlosz, E Betzig, ...
ACS chemical biology 8 (6), 1303-1310, 2013
Deep learning enables fast and dense single-molecule localization with high accuracy
A Speiser, LR Müller, P Hoess, U Matti, CJ Obara, WR Legant, A Kreshuk, ...
Nature methods 18 (9), 1082-1090, 2021
Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy
F Aguet, S Upadhyayula, R Gaudin, Y Chou, E Cocucci, K He, BC Chen, ...
Molecular biology of the cell 27 (22), 3418-3435, 2016
Real-time imaging of Huntingtin aggregates diverting target search and gene transcription
L Li, H Liu, P Dong, D Li, WR Legant, JB Grimm, LD Lavis, E Betzig, ...
Elife 5, e17056, 2016
Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis
WR Legant, CS Chen, V Vogel
Integrative Biology 4 (10), 1164-1174, 2012
Diffusion of MMPs on the surface of collagen fibrils: the mobile cell surface–collagen substratum interface
IE Collier, W Legant, B Marmer, O Lubman, S Saffarian, T Wakatsuki, ...
PloS one 6 (9), e24029, 2011
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