Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents K Kumar, D Awasthi, SY Lee, I Zanardi, B Ruzsicska, S Knudson, ... Journal of medicinal chemistry 54 (1), 374-381, 2010 | 199 | 2010 |
Discovery of anti-TB agents that target the cell-division protein FtsZ K Kumar, D Awasthi, WT Berger, PJ Tonge, RA Slayden, I Ojima Future 2 (8), 1305-1323, 2010 | 107 | 2010 |
SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents D Awasthi, K Kumar, SE Knudson, RA Slayden, I Ojima Journal of medicinal chemistry 56 (23), 9756-9770, 2013 | 90 | 2013 |
Drug discovery targeting cell division proteins, microtubules and FtsZ I Ojima, K Kumar, D Awasthi, JG Vineberg Bioorganic & medicinal chemistry 22 (18), 5060-5077, 2014 | 80 | 2014 |
A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived … P Sukheja, P Kumar, N Mittal, S Li, E Singleton, R Russo, AL Perryman, ... mBio 8 (1), e02022-16, 2017 | 79 | 2017 |
Design, synthesis and evaluation of novel 2, 5, 6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents B Park, D Awasthi, SR Chowdhury, EH Melief, K Kumar, SE Knudson, ... Bioorganic & medicinal chemistry 22 (9), 2602-2612, 2014 | 64 | 2014 |
Therapeutic potential of FtsZ inhibition: a patent perspective D Awasthi, K Kumar, I Ojima Expert opinion on therapeutic patents 21 (5), 657-679, 2011 | 61 | 2011 |
Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB NS Chandrasekera, BJ Berube, G Shetye, S Chettiar, T O’Malley, ... ACS infectious diseases, 2017 | 58 | 2017 |
Benzimidazole-based antibacterial agents against Francisella tularensis K Kumar, D Awasthi, SY Lee, JE Cummings, SE Knudson, RA Slayden, ... Bioorganic & medicinal chemistry 21 (11), 3318-3326, 2013 | 50 | 2013 |
SB-RA-2001 Inhibits Bacterial Proliferation by Targeting FtsZ Assembly D Singh, A Bhattacharya, A Rai, HPS Dhaked, D Awasthi, I Ojima, ... Biochemistry 53 (18), 2979-2992, 2014 | 43 | 2014 |
Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery D Awasthi, JS Freundlich Trends in Microbiology, 2017 | 40 | 2017 |
In vitro–in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis SE Knudson, K Kumar, D Awasthi, I Ojima, RA Slayden Tuberculosis 94 (3), 271-276, 2014 | 34 | 2014 |
A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis SE Knudson, D Awasthi, K Kumar, A Carreau, L Goullieux, S Lagrange, ... PloS one 9 (4), e93953, 2014 | 28 | 2014 |
Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model SE Knudson, D Awasthi, K Kumar, A Carreau, L Goullieux, S Lagrange, ... Journal of Antimicrobial Chemotherapy 70 (11), 3070-3073, 2015 | 23 | 2015 |
Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ I Ojima, D Awasthi, L Wei, K Haranahalli Journal of Fluorine Chemistry, 2016 | 18 | 2016 |