| Classification of intrinsically disordered regions and proteins R Van Der Lee, M Buljan, B Lang, RJ Weatheritt, GW Daughdrill, ... Chemical reviews 114 (13), 6589-6631, 2014 | 2210 | 2014 |
| Coexisting liquid phases underlie nucleolar subcompartments M Feric, N Vaidya, TS Harmon, DM Mitrea, L Zhu, TM Richardson, ... Cell 165 (7), 1686-1697, 2016 | 1837 | 2016 |
| A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins J Wang, JM Choi, AS Holehouse, HO Lee, X Zhang, M Jahnel, ... Cell 174 (3), 688-699. e16, 2018 | 1743 | 2018 |
| Polymer physics of intracellular phase transitions CP Brangwynne, P Tompa, RV Pappu Nature Physics 11 (11), 899-904, 2015 | 1487 | 2015 |
| Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues RK Das, RV Pappu Proceedings of the National Academy of Sciences 110 (33), 13392-13397, 2013 | 961 | 2013 |
| Valence and patterning of aromatic residues determine the phase behavior of prion-like domains EW Martin, AS Holehouse, I Peran, M Farag, JJ Incicco, A Bremer, ... Science 367 (6478), 694-699, 2020 | 849 | 2020 |
| Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein CW Pak, M Kosno, AS Holehouse, SB Padrick, A Mittal, R Ali, AA Yunus, ... Molecular cell 63 (1), 72-85, 2016 | 763 | 2016 |
| RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation J Guillén-Boixet, A Kopach, AS Holehouse, S Wittmann, M Jahnel, ... Cell 181 (2), 346-361. e17, 2020 | 710 | 2020 |
| Physical principles underlying the complex biology of intracellular phase transitions JM Choi, AS Holehouse, RV Pappu Annual review of biophysics 49 (1), 107-133, 2020 | 707 | 2020 |
| Phase separation of a yeast prion protein promotes cellular fitness TM Franzmann, M Jahnel, A Pozniakovsky, J Mahamid, AS Holehouse, ... Science 359 (6371), eaao5654, 2018 | 685 | 2018 |
| Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins TS Harmon, AS Holehouse, MK Rosen, RV Pappu elife 6, e30294, 2017 | 623 | 2017 |
| Net charge per residue modulates conformational ensembles of intrinsically disordered proteins AH Mao, SL Crick, A Vitalis, CL Chicoine, RV Pappu Proceedings of the National Academy of Sciences 107 (18), 8183-8188, 2010 | 611 | 2010 |
| Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles MT Wei, S Elbaum-Garfinkle, AS Holehouse, CCH Chen, M Feric, ... Nature chemistry 9 (11), 1118-1125, 2017 | 535 | 2017 |
| Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide X Hu, SL Crick, G Bu, C Frieden, RV Pappu, JM Lee Proceedings of the National Academy of Sciences 106 (48), 20324-20329, 2009 | 496 | 2009 |
| AlphaFold and implications for intrinsically disordered proteins KM Ruff, RV Pappu Journal of molecular biology 433 (20), 167208, 2021 | 486 | 2021 |
| CIDER: resources to analyze sequence-ensemble relationships of intrinsically disordered proteins AS Holehouse, RK Das, JN Ahad, MOG Richardson, RV Pappu Biophysical journal 112 (1), 16-21, 2017 | 463 | 2017 |
| Spontaneous driving forces give rise to protein− RNA condensates with coexisting phases and complex material properties S Boeynaems, AS Holehouse, V Weinhardt, D Kovacs, J Van Lindt, ... Proceedings of the National Academy of Sciences 116 (16), 7889-7898, 2019 | 434 | 2019 |
| Relating sequence encoded information to form and function of intrinsically disordered proteins RK Das, KM Ruff, RV Pappu Current opinion in structural biology 32, 102-112, 2015 | 415 | 2015 |
| A conceptual framework for understanding phase separation and addressing open questions and challenges T Mittag, RV Pappu Molecular cell 82 (12), 2201-2214, 2022 | 401 | 2022 |
| The Flory isolated-pair hypothesis is not valid for polypeptide chains: implications for protein folding RV Pappu, R Srinivasan, GD Rose Proceedings of the National Academy of Sciences 97 (23), 12565-12570, 2000 | 367 | 2000 |
Alex S. HolehouseAssistant Professor, Washington University in Saint LouisVerified email at wustl.edu
