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Tina Mutka
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Quinolone-3-diarylethers: a new class of antimalarial drug
A Nilsen, AN LaCrue, KL White, IP Forquer, RM Cross, J Marfurt, ...
Science translational medicine 5 (177), 177ra37-177ra37, 2013
2462013
Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity
RM Cross, A Monastyrskyi, TS Mutka, JN Burrows, DE Kyle, R Manetsch
Journal of medicinal chemistry 53 (19), 7076-7094, 2010
1382010
Epigenetic Tailoring for the Production of Anti-Infective Cytosporones from the Marine Fungus Leucostoma persoonii
J Beau, N Mahid, WN Burda, L Harrington, LN Shaw, T Mutka, DE Kyle, ...
Marine Drugs 10 (4), 762-774, 2012
1232012
Phenotypic and Genotypic Analysis of In Vitro-Selected Artemisinin-Resistant Progeny of Plasmodium falciparum
MS Tucker, T Mutka, K Sparks, J Patel, DE Kyle
Antimicrobial agents and chemotherapy 56 (1), 302-314, 2012
1052012
Optimization of 1, 2, 3, 4-tetrahydroacridin-9 (10H)-ones as antimalarials utilizing structure–activity and structure–property relationships
RM Cross, JR Maignan, TS Mutka, L Luong, J Sargent, DE Kyle, ...
American Chemical Society, 2011
832011
Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta
CL Shao, RG Linington, MJ Balunas, A Centeno, P Boudreau, C Zhang, ...
The Journal of Organic Chemistry 80 (16), 7849-7855, 2015
772015
Screening mangrove endophytic fungi for antimalarial natural products
L Calcul, C Waterman, WS Ma, MD Lebar, C Harter, T Mutka, L Morton, ...
Marine drugs 11 (12), 5036-5050, 2013
762013
Synthesis, Antimalarial Activity, and Structure–Activity Relationship of 7-(2-Phenoxyethoxy)-4(1H)-quinolones
RM Cross, NK Namelikonda, TS Mutka, L Luong, DE Kyle, R Manetsch
Journal of medicinal chemistry 54 (24), 8321-8327, 2011
712011
Orally Bioavailable 6-Chloro-7-methoxy-4(1H)-quinolones Efficacious against Multiple Stages of Plasmodium
RM Cross, DL Flanigan, A Monastyrskyi, AN LaCrue, FE Sáenz, ...
Journal of Medicinal Chemistry 57 (21), 8860-8879, 2014
422014
4(1H)-Quinolones with Liver Stage Activity against Plasmodium berghei
AN LaCrue, FE Sáenz, RM Cross, KO Udenze, A Monastyrskyi, S Stein, ...
Antimicrobial agents and chemotherapy 57 (1), 417-424, 2013
422013
Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro
FE Sáenz, T Mutka, K Udenze, AMJ Oduola, DE Kyle
Antimicrobial agents and chemotherapy 56 (9), 4685-4692, 2012
412012
Norselic Acids A−E, Highly Oxidized Anti-infective Steroids that Deter Mesograzer Predation, from the Antarctic Sponge Crella sp.
WS Ma, T Mutka, B Vesley, MO Amsler, JB McClintock, CD Amsler, ...
Journal of natural products 72 (10), 1842-1846, 2009
402009
CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs
MD Lebar, KN Hahn, T Mutka, P Maignan, JB McClintock, CD Amsler, ...
Bioorganic & medicinal chemistry 19 (19), 5756-5762, 2011
392011
Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure–Activity and Structure–Property …
R Neelarapu, JR Maignan, CL Lichorowic, A Monastyrskyi, TS Mutka, ...
Journal of medicinal chemistry 61 (4), 1450-1473, 2018
322018
ICI 56,780 Optimization: Structure–Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity
JR Maignan, CL Lichorowic, J Giarrusso, LD Blake, D Casandra, ...
Journal of medicinal chemistry 59 (14), 6943-6960, 2016
262016
Quinolone-3-diarylethers: a new class of antimalarial drug. Sci Transl Med 5: 177ra37
A Nilsen, AN LaCrue, KL White, IP Forquer, RM Cross, J Marfurt, ...
192013
Transition-metal-free one-pot tandem synthesis of 4-quinolone and 4H-thiochromen-4-one derivatives through sequential nucleophilic addition–elimination–SNAr reaction
D Wang, P Sun, P Jia, J Peng, Y Yue, C Chen
Synthesis 49 (18), 4309-4320, 2017
182017
Synthesis and activity of a new series of antileishmanial agents
A Kanwar, BJ Eduful, L Barbeto, P Carletti Bonomo, A Lemus, BA Vesely, ...
ACS Medicinal Chemistry Letters 8 (8), 797-801, 2017
132017
Miniaturized cultivation of microbiota for antimalarial drug discovery
C Waterman, L Calcul, J Beau, WS Ma, MD Lebar, JL von Salm, C Harter, ...
Medicinal Research Reviews 36 (1), 144-168, 2016
92016
A potent antimalarial trichothecene from hyphomycete species
C Waterman, L Calcul, T Mutka, DE Kyle, CJ Pearce, BJ Baker
Tetrahedron letters 55 (29), 3989-3991, 2014
82014
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