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J David Lawson
J David Lawson
Mirati Therapeutics
Verified email at mirati.com
Title
Cited by
Cited by
Year
Intrinsically disordered protein
AK Dunker, JD Lawson, CJ Brown, RM Williams, P Romero, JS Oh, ...
Journal of molecular graphics and modelling 19 (1), 26-59, 2001
29262001
Intrinsic disorder and protein function
AK Dunker, CJ Brown, JD Lawson, LM Iakoucheva, Z Obradović
Biochemistry 41 (21), 6573-6582, 2002
21512002
Intrinsic disorder in cell-signaling and cancer-associated proteins
LM Iakoucheva, CJ Brown, JD Lawson, Z Obradović, AK Dunker
Journal of molecular biology 323 (3), 573-584, 2002
14642002
Acquired Resistance to KRASG12C Inhibition in Cancer
MM Awad, S Liu, II Rybkin, KC Arbour, J Dilly, VW Zhu, ML Johnson, ...
New England Journal of Medicine 384 (25), 2382-2393, 2021
7492021
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor
X Wang, S Allen, JF Blake, V Bowcut, DM Briere, A Calinisan, JR Dahlke, ...
Journal of medicinal chemistry 65 (4), 3123-3133, 2021
4512021
Protein flexibility and intrinsic disorder
P Radivojac, Z Obradovic, DK Smith, G Zhu, S Vucetic, CJ Brown, ...
Protein Science 13 (1), 71-80, 2004
4112004
DisProt: a database of protein disorder
S Vucetic, Z Obradovic, V Vacic, P Radivojac, K Peng, LM Iakoucheva, ...
Bioinformatics 21 (1), 137-140, 2005
2942005
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor
J Hallin, V Bowcut, A Calinisan, DM Briere, L Hargis, LD Engstrom, ...
Nature medicine 28 (10), 2171-2182, 2022
2612022
Is myosin a" back door" enzyme?
RG Yount, D Lawson, I Rayment
Biophysical journal 68 (4 Suppl), 44S, 1995
1981995
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers
CR Smith, R Aranda, TP Bobinski, DM Briere, AC Burns, JG Christensen, ...
Journal of Medicinal Chemistry 65 (3), 1749-1766, 2022
822022
Fragment-based discovery of a small molecule inhibitor of Bruton’s tyrosine kinase
CR Smith, DR Dougan, M Komandla, T Kanouni, B Knight, JD Lawson, ...
Journal of Medicinal Chemistry 58 (14), 5437-5444, 2015
752015
Molecular dynamics analysis of structural factors influencing back door pi release in myosin
JD Lawson, E Pate, I Rayment, RG Yount
Biophysical journal 86 (6), 3794-3803, 2004
672004
Design and discovery of MRTX0902, a potent, selective, brain-penetrant, and orally bioavailable inhibitor of the SOS1: KRAS protein–protein interaction
JM Ketcham, J Haling, S Khare, V Bowcut, DM Briere, AC Burns, RJ Gunn, ...
Journal of Medicinal Chemistry 65 (14), 9678-9690, 2022
612022
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
LD Engstrom, R Aranda, L Waters, K Moya, V Bowcut, L Vegar, D Trinh, ...
Cancer discovery 13 (11), 2412-2431, 2023
452023
Structural model of the regulatory domain of smooth muscle heavy meromyosin
JL Wahlstrom, MA Randall, JD Lawson, DE Lyons, WF Siems, GJ Crouch, ...
Journal of Biological Chemistry 278 (7), 5123-5131, 2003
412003
A back-to-front fragment-based drug design search strategy targeting the DFG-out pocket of protein tyrosine kinases
H Iwata, H Oki, K Okada, T Takagi, M Tawada, Y Miyazaki, S Imamura, ...
ACS medicinal chemistry letters 3 (4), 342-346, 2012
342012
Fragment-based drug discovery of potent and selective MKK3/6 inhibitors
M Adams, T Kobayashi, JD Lawson, M Saitoh, K Shimokawa, SV Bigi, ...
Bioorganic & medicinal chemistry letters 26 (3), 1086-1089, 2016
262016
Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 2
C McBride, Z Cheruvallath, M Komandla, M Tang, P Farrell, JD Lawson, ...
Bioorganic & Medicinal Chemistry Letters 26 (12), 2779-2783, 2016
252016
Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1
Z Cheruvallath, M Tang, C McBride, M Komandla, J Miura, T Ton-Nu, ...
Bioorganic & medicinal chemistry letters 26 (12), 2774-2778, 2016
232016
Isolation of chloroform-resistant mutants of filamentous phage: localization in models of phage structure
JS Oh, DR Davies, JD Lawson, GE Arnold, AK Dunker
Journal of molecular biology 287 (3), 449-457, 1999
211999
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