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Kiersten M Ruff
Kiersten M Ruff
Verified email at wustl.edu
Title
Cited by
Cited by
Year
Relating sequence encoded information to form and function of intrinsically disordered proteins
RK Das, KM Ruff, RV Pappu
Current Opinion in Structural Biology 32, 102-112, 2015
3822015
AlphaFold and implications for intrinsically disordered proteins
KM Ruff, RV Pappu
Journal of Molecular Biology 433 (20), 167208, 2021
3692021
Inert and seed-competent tau monomers suggest structural origins of aggregation
H Mirbaha, D Chen, OA Morazova, KM Ruff, AM Sharma, X Liu, ...
Elife 7, e36584, 2018
2432018
Unmasking the roles of N-and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation
SL Crick, KM Ruff, K Garai, C Frieden, RV Pappu
Proceedings of the National Academy of Sciences 110 (50), 20075-20080, 2013
2292013
Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements
G Fuertes, N Banterle, KM Ruff, A Chowdhury, D Mercadante, C Koehler, ...
Proceedings of the National Academy of Sciences 114 (31), E6342-E6351, 2017
2072017
Advances in understanding stimulus-responsive phase behavior of intrinsically disordered protein polymers
KM Ruff, S Roberts, A Chilkoti, RV Pappu
Journal of molecular biology 430 (23), 4619-4635, 2018
1842018
Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers
AE Posey, KM Ruff, TS Harmon, SL Crick, A Li, MI Diamond, RV Pappu
Journal of Biological Chemistry 293 (10), 3734-3746, 2018
1132018
PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins
T Lazar, E Martínez-Pérez, F Quaglia, A Hatos, LB Chemes, JA Iserte, ...
Nucleic Acids Research 49 (D1), D404-D411, 2021
1112021
Ligand effects on phase separation of multivalent macromolecules
KM Ruff, F Dar, RV Pappu
Proceedings of the National Academy of Sciences 118 (10), e2017184118, 2021
1082021
Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
JB Warner IV, KM Ruff, PS Tan, EA Lemke, RV Pappu, HA Lashuel
Journal of the American Chemical Society 139 (41), 14456-14469, 2017
922017
Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations
KM Ruff, RV Pappu, AS Holehouse
Current opinion in structural biology 56, 1-10, 2019
842019
CAMELOT: A machine learning approach for coarse-grained simulations of aggregation of block-copolymeric protein sequences
KM Ruff, TS Harmon, RV Pappu
The Journal of chemical physics 143 (24), 12B607_1, 2015
812015
Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length
EA Newcombe, KM Ruff, A Sethi, AR Ormsby, YM Ramdzan, A Fox, ...
Journal of molecular biology 430 (10), 1442-1458, 2018
682018
Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome
L Ripaud, V Chumakova, M Antonin, AR Hastie, S Pinkert, R Körner, ...
Proceedings of the National Academy of Sciences 111 (51), 18219-18224, 2014
602014
Sequence grammar underlying the unfolding and phase separation of globular proteins
KM Ruff, YH Choi, D Cox, AR Ormsby, Y Myung, DB Ascher, SE Radford, ...
Molecular cell 82 (17), 3193-3208. e8, 2022
522022
Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins
X Zeng, KM Ruff, RV Pappu
Proceedings of the National Academy of Sciences 119 (19), e2200559119, 2022
442022
A Coarse-Grained Model for Polyglutamine Aggregation Modulated by Amphipathic Flanking Sequences
KM Ruff, SJ Khan, RV Pappu
Biophysical Journal 107 (5), 1226-1235, 2014
382014
Polyphasic linkage and the impact of ligand binding on the regulation of biomolecular condensates
KM Ruff, F Dar, RV Pappu
Biophysics Reviews 2 (2), 021302, 2021
352021
Comment on “Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water”
G Fuertes, N Banterle, KM Ruff, A Chowdhury, RV Pappu, DI Svergun, ...
Science 361 (6405), eaau8230, 2018
332018
Information theoretic measures for quantifying sequence–ensemble relationships of intrinsically disordered proteins
MC Cohan, KM Ruff, RV Pappu
Protein Engineering, Design and Selection 32 (4), 191-202, 2019
272019
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