Kiersten M Ruff
Kiersten M Ruff
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Relating sequence encoded information to form and function of intrinsically disordered proteins
RK Das, KM Ruff, RV Pappu
Current Opinion in Structural Biology 32, 102-112, 2015
AlphaFold and implications for intrinsically disordered proteins
KM Ruff, RV Pappu
Journal of Molecular Biology 433 (20), 167208, 2021
Inert and seed-competent tau monomers suggest structural origins of aggregation
H Mirbaha, D Chen, OA Morazova, KM Ruff, AM Sharma, X Liu, ...
Elife 7, e36584, 2018
Unmasking the roles of N-and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation
SL Crick, KM Ruff, K Garai, C Frieden, RV Pappu
Proceedings of the National Academy of Sciences 110 (50), 20075-20080, 2013
Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements
G Fuertes, N Banterle, KM Ruff, A Chowdhury, D Mercadante, C Koehler, ...
Proceedings of the National Academy of Sciences 114 (31), E6342-E6351, 2017
Advances in understanding stimulus-responsive phase behavior of intrinsically disordered protein polymers
KM Ruff, S Roberts, A Chilkoti, RV Pappu
Journal of molecular biology 430 (23), 4619-4635, 2018
Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers
AE Posey, KM Ruff, TS Harmon, SL Crick, A Li, MI Diamond, RV Pappu
Journal of Biological Chemistry 293 (10), 3734-3746, 2018
PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins
T Lazar, E Martínez-Pérez, F Quaglia, A Hatos, LB Chemes, JA Iserte, ...
Nucleic Acids Research 49 (D1), D404-D411, 2021
Ligand effects on phase separation of multivalent macromolecules
KM Ruff, F Dar, RV Pappu
Proceedings of the National Academy of Sciences 118 (10), e2017184118, 2021
Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
JB Warner IV, KM Ruff, PS Tan, EA Lemke, RV Pappu, HA Lashuel
Journal of the American Chemical Society 139 (41), 14456-14469, 2017
Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations
KM Ruff, RV Pappu, AS Holehouse
Current opinion in structural biology 56, 1-10, 2019
CAMELOT: A machine learning approach for coarse-grained simulations of aggregation of block-copolymeric protein sequences
KM Ruff, TS Harmon, RV Pappu
The Journal of chemical physics 143 (24), 12B607_1, 2015
Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length
EA Newcombe, KM Ruff, A Sethi, AR Ormsby, YM Ramdzan, A Fox, ...
Journal of molecular biology 430 (10), 1442-1458, 2018
Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome
L Ripaud, V Chumakova, M Antonin, AR Hastie, S Pinkert, R Körner, ...
Proceedings of the National Academy of Sciences 111 (51), 18219-18224, 2014
Sequence grammar underlying the unfolding and phase separation of globular proteins
KM Ruff, YH Choi, D Cox, AR Ormsby, Y Myung, DB Ascher, SE Radford, ...
Molecular cell 82 (17), 3193-3208. e8, 2022
Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins
X Zeng, KM Ruff, RV Pappu
Proceedings of the National Academy of Sciences 119 (19), e2200559119, 2022
A Coarse-Grained Model for Polyglutamine Aggregation Modulated by Amphipathic Flanking Sequences
KM Ruff, SJ Khan, RV Pappu
Biophysical Journal 107 (5), 1226-1235, 2014
Polyphasic linkage and the impact of ligand binding on the regulation of biomolecular condensates
KM Ruff, F Dar, RV Pappu
Biophysics Reviews 2 (2), 021302, 2021
Comment on “Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water”
G Fuertes, N Banterle, KM Ruff, A Chowdhury, RV Pappu, DI Svergun, ...
Science 361 (6405), eaau8230, 2018
Information theoretic measures for quantifying sequence–ensemble relationships of intrinsically disordered proteins
MC Cohan, KM Ruff, RV Pappu
Protein Engineering, Design and Selection 32 (4), 191-202, 2019
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