Joshua Woodward
Joshua Woodward
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c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response
JJ Woodward, AT Iavarone, DA Portnoy
Science 328 (5986), 1703-1705, 2010
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
J Fu, DB Kanne, M Leong, LH Glickman, SM McWhirter, E Lemmens, ...
Science translational medicine 7 (283), 283ra52-283ra52, 2015
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic …
JD Sauer, K Sotelo-Troha, J Von Moltke, KM Monroe, CS Rae, ...
Infection and immunity 79 (2), 688-694, 2011
Cutting edge: cGAS is required for lethal autoimmune disease in the Trex1-deficient mouse model of Aicardi–Goutières syndrome
EE Gray, PM Treuting, JJ Woodward, DB Stetson
The Journal of Immunology 195 (5), 1939-1943, 2015
SLC19A1 transports immunoreactive cyclic dinucleotides
RD Luteijn, SA Zaver, BG Gowen, SK Wyman, NE Garelis, L Onia, ...
Nature 573 (7774), 434-438, 2019
Replication-transcription conflicts generate R-loops that orchestrate bacterial stress survival and pathogenesis
KS Lang, AN Hall, CN Merrikh, M Ragheb, H Tabakh, AJ Pollock, ...
Cell 170 (4), 787-799. e18, 2017
The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function
K Sureka, PH Choi, M Precit, M Delince, DA Pensinger, TAN Huynh, ...
Cell 158 (6), 1389-1401, 2014
Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection
CE Witte, AT Whiteley, TP Burke, JD Sauer, DA Portnoy, JJ Woodward
MBio 4 (3), 10.1128/mbio. 00282-13, 2013
An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence
TAN Huynh, S Luo, D Pensinger, JD Sauer, L Tong, JJ Woodward
Proceedings of the National Academy of Sciences 112 (7), E747-E756, 2015
Cutting edge: antimalarial drugs inhibit IFN-β production through blockade of cyclic GMP-AMP synthase–DNA interaction
J An, JJ Woodward, T Sasaki, M Minie, KB Elkon
The Journal of Immunology 194 (9), 4089-4093, 2015
Expression of cyclic GMP‐AMP synthase in patients with systemic lupus erythematosus
J An, L Durcan, RM Karr, TA Briggs, GI Rice, TH Teal, JJ Woodward, ...
Arthritis & rheumatology 69 (4), 800-807, 2017
Antimalarial drugs as immune modulators: new mechanisms for old drugs
J An, M Minie, T Sasaki, JJ Woodward, KB Elkon
Annual review of medicine 68, 317-330, 2017
Sensing of bacterial cyclic dinucleotides by the oxidoreductase RECON promotes NF-κB activation and shapes a proinflammatory antibacterial state
AP McFarland, S Luo, F Ahmed-Qadri, M Zuck, EF Thayer, YA Goo, ...
Immunity 46 (3), 433-445, 2017
Development of a mariner-Based Transposon and Identification of Listeria monocytogenes Determinants, Including the Peptidyl-Prolyl Isomerase PrsA2, That …
J Zemansky, BC Kline, JJ Woodward, JH Leber, H Marquis, DA Portnoy
Journal of bacteriology 191 (12), 3950-3964, 2009
Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity
CE Witte, KA Archer, CS Rae, JD Sauer, JJ Woodward, DA Portnoy
Advances in immunology 113, 135-156, 2012
c‐di‐AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation
AT Whiteley, NE Garelis, BN Peterson, PH Choi, L Tong, JJ Woodward, ...
Molecular microbiology 104 (2), 212-233, 2017
Listeria monocytogenes in Food-Processing Facilities, Food Contamination, and Human Listeriosis: The Brazilian Scenario
AC Camargo, JJ Woodward, DR Call, LA Nero
Foodborne Pathogens and Disease 14 (11), 623-636, 2017
Cyclic di‐AMP targets the cystathionine beta‐synthase domain of the osmolyte transporter OpuC
TAN Huynh, PH Choi, K Sureka, HE Ledvina, J Campillo, L Tong, ...
Molecular microbiology 102 (2), 233-243, 2016
Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm
TAN Huynh, JJ Woodward
Current opinion in microbiology 30, 22-29, 2016
Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state
S Stoll, Y NejatyJahromy, JJ Woodward, A Ozarowski, MA Marletta, ...
Journal of the American Chemical Society 132 (33), 11812-11823, 2010
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